TNFSF11

TNFSF11
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3URF, 5BNQ
Dynodwyr
Cyfenwau	TNFSF11, CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf, TNLG6B, tumor necrosis factor superfamily member 11, TNF superfamily member 11
Dynodwyr allanol	OMIM: 602642 HomoloGene: 2744 GeneCards: TNFSF11
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• cytokine activity; • tumor necrosis factor receptor superfamily binding; • tumor necrosis factor receptor binding; • GO:0001948, GO:0016582 protein binding;
Cydrannau o'r gell	• cytoplasm; • integral component of membrane; • bilen; • Cellbilen; • integral component of plasma membrane; • extracellular region; • extracellular space;
Prosesau biolegol	• mammary gland epithelial cell proliferation; • cell differentiation; • positive regulation of protein kinase B signaling; • positive regulation of corticotropin-releasing hormone secretion; • positive regulation of MAP kinase activity; • calcium ion homeostasis; • ossification; • monocyte chemotaxis; • cytokine-mediated signaling pathway; • osteoclast differentiation; • ERK1 and ERK2 cascade; • paracrine signaling; • positive regulation of DNA-binding transcription factor activity; • positive regulation of osteoclast differentiation; • tumor necrosis factor-mediated signaling pathway; • GO:0010740 positive regulation of intracellular signal transduction; • positive regulation of bone resorption; • mammary gland alveolus development; • positive regulation of JNK cascade; • bone resorption; • positive regulation of osteoclast development; • multicellular organism development; • positive regulation of T cell activation; • positive regulation of homotypic cell-cell adhesion; • positive regulation of NF-kappaB transcription factor activity; • positive regulation of fever generation by positive regulation of prostaglandin secretion; • positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling; • regulation of osteoclast differentiation; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • animal organ morphogenesis; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • TNFSF11-mediated signaling pathway; • positive regulation of phosphorylation; • protein homooligomerization; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • osteoclast proliferation; • calcium-mediated signaling; • cellular response to leukemia inhibitory factor; • regulation of signaling receptor activity; • tooth eruption; • bone development; • GO:1901313 positive regulation of gene expression; • osteoclast development; • regulation of actin binding;
	Sources:Amigo / QuickGO
Orthologau
	8600
	n/a
	ENSG00000120659
	n/a
	O14788
	n/a
	NM_003701; NM_033012
	n/a
	NP_003692; NP_143026
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TNFSF11 yw TNFSF11 a elwir hefyd yn TNF superfamily member 11 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 13, band 13q14.11.^[2]

[1] "Human PubMed Reference:".

[2] TNFSF11 - Cronfa NCBI

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